The International Space Station (ISS) operates on a five-day work and two-day rest schedule, mirroring Earth's workweek rhythm. This deliberate design choice is not merely a nostalgic nod to Earthly norms but a strategic decision rooted in decades of data and experience. The story of Skylab 4 in 1973 serves as a crucial lesson in the importance of structured rest and downtime for astronauts. During this mission, the crew's productivity suffered due to an overloaded schedule, leading to strained communication and frustration. NASA's restructuring of the mission, which included protected rest periods and more free time, significantly improved the crew's performance in the second half of the mission. This incident highlights the idea that performance over extended periods is not a straight line but a resource that needs replenishment. Packing a schedule to eliminate this replenishment can lead to degradation in output rather than maximization. NASA's approach to scheduling on the ISS is a direct response to this understanding. By offering astronauts opportunities to decompress, NASA recognizes that rest is not a perk but a critical component of the mission. This is evident in the diverse activities astronauts engage in during their weekends, such as journaling, observing Earth from the Cupola module, and playing musical instruments. This deliberate engineering decision aligns with the broader understanding of knowledge work, where rest is not time lost but an essential part of the structure that enables productive working days. The default assumption that more hours spent working equate to more output is flawed. In reality, the quality of work on a Monday following a rested weekend is significantly different from the quality of work on a Monday after a weekend of continuous work. This distinction is not subtle, and acknowledging it is crucial for optimizing productivity. The ISS's schedule, therefore, serves as a powerful reminder that rest is not a luxury but a necessity for optimal performance, whether in space or on Earth.